Laboratory of Developmental Programming
and Immuno-Physiology

Lim J†, Lin EV†, Hong JY†*, Vaidyanathan B, Erickson SA, Annicelli C, Medzhitov R* Induction of natural IgE by glucocorticoids. J Exp Med 219:e20220903 (2022)​. (†co-first authors, *co-correspondence)

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Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung J-J, Yan Q, Liu Y, Choi J, and Wysolmerski J.  MAL2 mediates the formation of stableHER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Reports  37: 110160 (2021).

 

Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Vesely MCA, Kim WJ, Koo J-H, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi J-M, Bothwell ALM.  Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. iScience. 24:102411 (2021).

 

Hong JY, Lim J, Carvalho F, Cho JY, Vaidyanathan B, Yu S, Annicelli C, IP EWK, Medzhitov R, Long-term programming of CD8 T cell immunity by perinatal exposure to glucocorticoids. Cell 180: 847-861.e15 (2020). [Previewed in the issue, Highlighted in Science, Previewed in Immunity].

 

Han M, Rajput C, Hong JY, Lei J, Hinde JL, Wu Q, Bentley JK, Hershenson MB, The innate cytokines IL-25, IL-33 and TSLP cooperate in the induction of ILC2 expansion and mucous metaplasia in rhinovirus-infected immature mice. J Immunol 199:1308-1318 (2017).

 

Han M*, Hong JY*, Jaipalli S, Rajput C, Lei J, Hinde JL, Chen Q, Hershenson NM, Bentley JK, Hershenson MB, IFN-γ blocks development of an asthma phenotype in rhinovirus-infected baby mice by inhibiting ILC2s. Am J Respir Cell Mol Biol. 56:242-251 (2017). (*co-first authors)

 

Han M, Chung Y, Hong JY, Rajput C, Lei J, Hinde JL, Chen Q, Weng ST, Bentley JK, Hershenson MB. TLR2-expressing macrophages are required and sufficient for rhinovirus-induced airway inflammation. J Allergy Clin Immunol 138:1619-1630 (2016).

 

Cui T, Maheshwer B, Hong JY, Goldsmith AM, Bentley JK, Popova AP. Hyperoxic Exposure of Immature Mice Increases the Inflammatory Response to Subsequent Rhinovirus Infection: Association with Danger Signals.  J Immunol 196:4692-705 (2016).

 

Chung Y, Hong JY, Lei J, Chen Q, Bentley JK, Hershenson MB. Rhinovirus infection induces IL-13 production from CD11b-positive, M2-polarized exudative macrophages. Am J Respir Cell Mol Biol. 52:205-16 (2015).

 

Bentley JK, Chen Q, Lei J, Hong JY, Popova AP, Moore BB, Hershenson MB. Periostin is required for maximal airways inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 134:1433-42 (2014).

 

Hong JY, Bentley JK, Chung Y, Lei J, Steenrod JM, Chen Q, Sajjan US, Hershenson MB. Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness via IL-25 and ILC2s. J Allergy Clin Immunol. 134:429-39 (2014) [Editor’s choice article].

 

Hong JY, Chung Y, Steenrod J, Chen Q, Lei J, Comstock AT, Goldsmith AM, Zhao Y, Bentley JK, Sajjan US, Hershenson MB. Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma. Respir Res 15:63 (2014).

 

Chung Y, Saba T, Hong JY, Sajjan US, Bentley JK, Hershenson MB. Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication Am J Respir Cell Mol Biol 50:974-84 (2014).

 

Schneider D, Hong JY, Bowman ER, Chung Y, Nagarkar DR, McHenry CL, Goldsmith AM, Bentley JK, Lewis TC, Hershenson MB. Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease. Am J Physiol Lung Cell Mol Physiol 304:L162-9 (2013).

 

Schneider D, Hong JY, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley JK, Weinberg JB, Lukacs NW, Curtis JL, Sajjan US, Hershenson MB. Neonatal rhinovirus infection induces persistent mucous metaplasia and airways hyperresponsiveness. J Immunol 188:2894-904 (2012).

 

Chin J*,  Hong JY*, Lee J*, , Hwang H, Ko H, Choi H, Hahn D, Ko J, Nam S, Tak J, Ham J, Kang H. Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo.  Bioorg Med Chem Lett 20, 7239-7242 (2010). (*co-first authors)